The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells
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چکیده
منابع مشابه
Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.
Cyclophosphamide (CPA), a widely used oxazaphosphorine anti-cancer prodrug, is inactive until it is metabolized by cytochrome P450 to yield phosphoramide mustard and acrolein, which alkylate DNA and proteins, respectively. Tumor cells transduced with the human cytochrome P450 gene CYP2B6 are greatly sensitized to CPA, however, the pathway of CPA-induced cell death is unknown. The present study ...
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ژورنال
عنوان ژورنال: Anti-Cancer Drugs
سال: 2009
ISSN: 0959-4973
DOI: 10.1097/cad.0b013e32832ae55f